Paper
Alterations in Serum Magnesium after an Acute Dose of Magnesium Citrate or Magnesium Amino Acid Chelate
Published Jul 1, 2002 · A. Fogarty, S. Christie, S. Lewis
Clinical Drug Investigation
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Abstract
Magnesium has potential therapeutic applications in several areas of clinical medicine, and given intravenously it has been shown to have a role in the acute management of pre-eclampsia,[1] myocardial infarction[2] and exacerbations of asthma.[3] However, the application of some oral magnesium compounds such as magnesium oxide and magnesium hydroxide in these circumstances is limited by the relatively poor absorption profiles of these forms of magnesium. These latter compounds are unlikely to have a marked effect on serum magnesium levels necessary to achieve values of approximately 2 mmol/L[4,5] that are of known benefit in diseases such as asthma. However, magnesium citrate is an organically bound magnesium compound that is more watersoluble, more bioavailable and has a better shortterm absorption profile, as assessed by urinary excretion and total serum levels at 4 hours, compared with other magnesium preparations such as magnesium oxide.[6] To determine the peak elevation of serum magnesium and the time-course of this effect, we compared serum magnesium levels over the first 4 hours after administration of a single oral dose of 300mg elemental magnesium of either magnesium citrate, magnesium amino acid chelate or placebo in healthy adult volunteers. Subjects and Methods
Magnesium citrate has a better short-term absorption profile than magnesium amino acid chelate, resulting in higher serum magnesium levels within 4 hours of administration.
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